This test provides a detailed insight into estrone, estradiol, estriol, metabolism, as well as the efficiency of COMT (methylation activity). This non-invasive test requires only 4 or 5 separate urine collections.

Because the breakdown of hormones relies so heavily on processes within the liver, this test can also elucidate areas of interest as it pertains to conjugation of each metabolite.

Furthermore, testing urinary hormone metabolites can contribute to further understanding of endogenous hormone secretion, supplemental hormone utilization, enzyme activity, oxidative stress, and insight into whether your body is safely metabolizing hormones. This profile is a consideration for baseline or follow up testing for patients with concerns that are particular to estrogens and/or monitoring for harmful metabolites due to the influence of HRT/BHRT.

When To Order This Test:

• If you suffer with PMS, fatigue, uterine fibroids, low libido, low mood, anxiety, depression, fibrocystic breast lumps, weight gain, endometriosis, headaches, breast tenderness or infertility

• If you suspect you are in perimenopause or going through menopause

• If you are on HRT.

Analytes:

• 16a-Hydroxyestrone (16-OH-E1)

• 2-Hydroxyesterone (2-OH-E1)

• 2-Hydroxyestradiol (2-OH-E2)

• 2-Methoxyestradiol (2-M-E2)

• 2-Methoxyestrone (2-M-E1)

• 4-Hydroxyestradiol (4-OH-E2)

• 4-Hydroxysterone (4-OH-E1)

• 4-Methoxyestradiol (4-M-E2)

• 4-Methoxyestrone (4-M-E1)

• Creatinine/day

• Estradiol (E2)

• Estriol (E3)

• Estrone (E1)