Urinary 8-hydroxy-2-deoxyguanosine (8-OHdG) is an excellent biomarker of ongoing oxidative damage or stress in the body. Reactive Oxygen Species (ROS) are produced as a result of normal oxygen metabolism or exposure to xenobiotics and excessive levels are associated with oxidative damage to lipids, proteins and DNA.
ROS induced damage to nuclear and mitochondrial DNA occurs readily at the guanosine bases that are removed by DNA repair mechanisms and excreted in urine. 8-OHdG is the most frequently detected and studied oxidised nucleoside of DNA that is considered premutagenic. When 8-OHdG levels are elevated it is important to identify the source of stress and inflammation and consider assessing glutathione, the primary intracellular antioxidant.
This test is useful for those with oxidative stress, metabolic syndrome, environmental exposure, inflammatory bowel disease, diabetes complications, atopic dermatitis, Alzheimer’s, hepatitis, cystic fibrosis, pancreatitis, Parkinson’s, rheumatoid arthritis, Huntington’s Disease or cancer.
Analytes:
- 8-hydroxy-2'-deoxyguanosine (8-OHdG)
DNA Oxidative Damage Urine Test
All ordered tests will be mediated by our Naturopath, Lekita Davies. Once test results have been returned to us, Lekita will call the client to deliver the results and discuss anything appropriate for the case. After the phone call, results will be emailed to the client alongside any suggestions. Please note that we cannot deliver results without a phone call.